This is a list of players that become eligible for the Rule 5 Draft in 2021.
Note: Players from the previous years Rule 5 drafts may still be eligible.
2021 Rule 5 Eligible Players
| Player | Position | Acquired | Signing Date | Free Agent Yr | MLB 40-Man |
|---|---|---|---|---|---|
| Hemmanuel Rosario | Catcher | Free Agent | 7/2/2017 | 2023 | No |
| Roberto Chirinos | Shortstop | Free Agent | 7/2/2017 | 2024 | No |
| Jose Martinez | Third Baseman | Free Agent | 7/2/2017 | 2024 | No |
| Ezequiel Duran | Second Baseman | Free Agent | 7/2/2017 | 2024 | No |
| Luis Santos | Shortstop | Free Agent | 5/25/2017 | 2023 | No |
| Starlin Paulino | Shortstop | Free Agent | 5/12/2017 | 2023 | No |
| Juan Carderon | Right-Handed Pitcher | Free Agent | 8/30/2016 | 2023 | No |
| Daison Manzano | Right-Handed Pitcher | Free Agent | 05/05/2017 | 2023 | No |
| Daniel Calderon | Left-Handed Pitcher | Free Agent | 09/15/2016 | 2023 | No |
| Robert Javier | Outfielder | Free Agent | 03/17/2017 | 2023 | No |
| Gabriel Mora | Catcher | Free Agent | 09/01/2016 | 2023 | No |
| Thowar Martinez | Right-Handed Pitcher | Free Agent | 2/9/2018 | 2024 | No |
| Silvio Morays | Right-Handed Pitcher | Free Agent | 2/9/2018 | 2024 | No |
| Carlos Moreno | Shortstop | Free Agent | 2/9/2018 | 2024 | No |
| Matt Sauer | Right-Handed Pitcher | Draft | 6/24/2017 | 2024 | No |
| Everson Pereira | Outfielder | Free Agent | 7/2/2017 | 2024 | No |
| Canaan Smith | Outfielder | Draft | 6/26/2017 | 2024 | No |